8-異構(gòu)前列腺素(8-Isoprostane)，別名15-異前列腺素F2t(15-isoprostane F2t)、8-異前列腺素F2α(iPF2α-III,8-epi-prostaglandin F2α, 8-iso-prostaglandin F2α)，是一類非酶來源的類二十烷，由氧自由基隨機氧化組織磷脂產(chǎn)生。8-異構(gòu)前列腺素是氧化損傷的最佳標志物，與冠狀動脈鈣化（CAC）增加有關(guān)。此外，8-異構(gòu)前列腺素水平在重度高血壓老年受試者血漿和高脂飲食引起的肝脂肪變性患者尿液中升高。血管緊張素II受體拮抗劑替米沙坦（高血壓藥物）顯著降低肝臟8-異構(gòu)前列腺素水平。8-異構(gòu)前列腺素已被檢測為運動誘導(dǎo)的肌肉損傷生物標志物和用于評估社區(qū)健康的污水生物標志物。

Detroit R&D 品牌8-Isoprostane Oxidative Stress ELISA試劑盒使用競爭法ELISA檢測正確分離和純化類二十烷之后的生物樣本如尿液、血清、血漿、細胞和組織中及廢水樣本中8-異前列腺素的濃度。稀釋的尿液和未經(jīng)提取的細胞培養(yǎng)基也適用于本試劑盒。

產(chǎn)品詳情

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部分產(chǎn)品文獻引用

1. Schottker, B et al. Oxidatively damaged DNA/RNA and 8-isoprostane levels are associated with the development of type 2 diabetes at older age: Results from a large cohort study. Diabetes Care, doi: 10.2337/dc19-1379. 2019

2. Gào X, Xuan Y, Benner A, Anusruti A, Brenner H, Sch?ttker, B. Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort. Oxidative Medicine and Cellular Longevity Volume 2019, Article ID 6470950, doi: 10.1155/2019/6470950 2

3. Kawasaki K, Kondoh E, Chigusa Y, Kawamura Y, Mogami H, Takeda S, Horie A, Baba T, Matsumura N, Mandai M, Konishi I. Metabolomic profiles of placenta in preeclampsia: Antioxidant effect of magnesium sulfate on trophoblasts in early-onset preeclampsia. Hypertension 73: 671-679. 2019.

4. Gào X, Zhang Y, Burwinkel B, Xuan Y, Holleczek B, Brenner H, Sch?ttker B. The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study. Clinical Epigenetics 11: 14-22. 2019.

5. Gao, X, Gào X, Zhang Y, Holleczek B, Sch?ttker B, Brenner H. Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people. Eur. J. Epidemiology 34: 451-462. 2019.

6. Gào X, Brenner H, Holleczek B, Cuk K, Zhang Y, Anusruti A, Xuan Y, Xu Y, Sch?ttker B. Urinary isoprostane levels and occurrence of lung, colorectal, prostate, breast and overall cancer: Results from a large, population-based cohort study with 14 years of follow-up. Free Radical Biology and Medicine 123: 20-26. 2018.

7. Santos, JM et al. The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes. Molecular and Cellular Biochemistry doi.org/10.1007/s11010-018- 3361-5. 2018.

8. Liu, LP et al. Deletion of soluble epoxide hydrolase attenuates mice hyperoxic acute lung injury. BMC Anesthesiology doi.org/10.1186/s/12871-018-0490-z. 2018

Detroit R&D公司由Dr. Hyesook Kim創(chuàng)立于1997年，Detroit R&D通過領(lǐng)-先的技術(shù)提供優(yōu)質(zhì)產(chǎn)品，致力于贏得科研工作者的絕對信任。Detroit R&D的特色產(chǎn)品涉及環(huán)境健康科學(xué)、高血壓、乳腺癌和前列腺癌相關(guān)研究領(lǐng)域，包括類花生酸生物活性研究相關(guān)產(chǎn)品，如EET,DHET和20-HETE；環(huán)境雌激素產(chǎn)品，如BPA，PGHS（也叫COX）；細胞色素P450（CYPs）;谷胱甘肽S-轉(zhuǎn)移酶(GSTs);氧化應(yīng)激；DNA損傷；非洲爪蟾蜍；藥物代謝；乳腺和前列腺微陣列；創(chuàng)傷修復(fù)等相關(guān)產(chǎn)品。

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